mseries

M-Series SIP Bioreactors/Fermenters

M series are steam in place bioreactors/fermenters available in a range of volumes from 30 up to 200 litres.

  • Standard sterilizable in place solutions.
  • Instrumentation for control and measurement of pH, Eh, dO2, CO2, RPM, Gas Mixing, Temperature, Antifoam, Feeds, turbidity, weight,etc. SCADA Control System.
  • Designed for microbial and cell fermentation.
  • Complete range of accessories
Vessel
Solaris Code M series 30 M series 50 M series 75 M series 100 M series 150 M series 200
Total Volume (liters) 30,00 50,00 75,00 100,00 150,00 200,00
Ratio D/H 1:2,5 1:2,5 1:2,5 1:2,5 1:2,5 1:2,5
Min. Working Volume (liters) 4,50 7,50 11,00 15,00 22,00 30,00
Max. Working Volume (liters) 21,00 36,00 55,00 75,00 110,00 145,00
Working temperature range 0-135°C
Working pressure range < 0.5bar
Design Stainless Steel Jacketed Vessel
Materials Parts in contact with the culture AISI 316 L – other parts AISI 304
Stirring
Drive Brushless Motor, Bottom Direct Assembly
Impellers Select from: Rushtons impellers, Marine Impellers, Pitched blade
Thermoregulation
Control

PID Control – Accuracy 0,1 °C

Jacket steam and electric heaters / cooling source

Gas control & gas mixing
Sparger and overlay Gas Control TMFC
Gas Mixing (Air,CO2,O2,N2) n.1 TMFC + n.4 solenoid valves, n° of TMFC
Sparger type Select from: Toro type (ring), syntered microbubbling both provided with 0,2 µm filter
Exhaust Condenser and 0,2 µm filter
Temperature
Sensor PT100
Control system Measuring resident in Leonardo 2.0 software
Control range 0 – 150°C
pH
Sensor Digital Hamilton sensor
Control system Measuring resident in Leonardo 2.0 software
Control range 0 – 14
Operation temperature 0 – 130°C
Pressure range 0 – 6 bar
Actuator Cascade to peristlatic pumps for the addition of acid/base solutions or gas (CO2)
dO2
Sensor Digital Digital Optical Hamilton sensor
Control system Measuring resident in Leonardo 2.0 software
Control range 0,05 – 300% air saturation
Operation temperature -10 – 130°C
Pressure range 0 – 12 bar
Actuator Cascade to RPM, Gas Control, feedings,etc
dCO2
Sensor Mettler Toledo sensor
Control system Measuring resident in Leonardo 2.0 software
Control range 0,00-200% saturation
Operation temperature -20.0-150°C
Pressure range 0 – 4 bar
Turbidity
Sensor Mettler Toledo sensor
Control system Measuring resident in Leonardo 2.0 software
Measuring range 0-250 g/L, 10-4000 FTU
Cell density
Sensor Hamilton-Fogale sensor
Control system Measuring resident in Leonardo 2.0 software
Option 1 Total cell density (Two ranges: 10^5 to 10^8 mammalian cells/ml – 0.5 to 300 g/L dry weight)
Option 2 Viable cell density (Two ranges: 5×10^5 to 8×10^8 mammalian cells/ml – 5 to 200 g/L dry weight)
Redox (ORP)
Sensor Digital Hamilton sensor
Control system Measuring resident in Leonardo 2.0 software
Control range ±2000 mV
Operation temperature – 10 -130°C
Pressure range ≤ 6 bar
Conductivity
Sensor Digital Hamilton sensor
Control system Measuring resident in Leonardo 2.0 software
Control range 1 – 3000 μS/cm
Operation temperature 0 -130°C
Pressure range 0 – 20 bar
Weight
Sensor n.3 load cells
Control Measuring resident in Leonardo 2.0 software
Antifoam/Level
Sensor Solaris sensor
Control Measuring resident in Leonardo 2.0 software