genesis

Genesis SIP Benchtop Fermenter/Bioreactor

GENESIS is R&D Sterizable-In-Place Benchtop Bioreactor/Fermenter available from 7,5 up to 20 litres total volume. It is ideal for the scale up fermentation, for pilot through production processes.

  • Automatic sterilization through electric heaters (no need for an external steam source) or alternative by steam.
  • Pre-definited system consist of all items needed for robust and advantageous operation.
  • GENESIS is an ideal partner for microbial fermentation as well as animal, plant and insect cell cultivation.
  • It can be used for: Biopharmaceutical, Biofuels research and manufacturing, Vaccines, Food and beverage biotechnologies, Bioremediation, Bioplastics, Cosmeceutical, Nutraceutical.
  • User-friendly fermentation and cultivation management
  • Innovative PARALLEL process control
  • Remote control for after sale assistance
  • Remote access via PC or tablet/smartphone
  • dO2 and pH cascade control
  • Up to four integrated pumps capable of operating in variable speed
  • mode and additional externals brushless pumps
  • Up to 24 vessels managed with one station.
  • Leda Sampling System
  • Toro, fluted and sintered spargers

Vessel

Solaris Code Genesis 7.5 Genesis 10.0 Genesis 15.0 Genesis 20.0
Total Volume (liters) 7.5 10.0 15.0 20.0
Ratio D/H 1:2,5 1:2,5 1:2,5 1:2,5
Min. Working Volume (liters) 1.1 1.5 2.25 2.95
Max. Working Volume (liters) 5.45 7.25 10.85 14.5
Working temperature range 0-135°C
Working pressure range < 0.5bar
Design Stainless Steel Jacketed Vessel
Materials Parts in contact with the culture AISI 316 L – other parts AISI 304

Ports and Connections

Connection Quantity Description
      Vessel lid PG13,5 3 Sampling
A.F.
Spare (Camera housing)
TC 3/4” 2 Safety Valve
Gas-out
TK 3/4” 1 SALAS – Solaris Sterile Liquid Addition System
TC 1” 2 Pressure probe
Lamp
1
DN52 Stirrer
Upper side wall TC 1/2″ 1 Overlay gas inlet
TC 1/2″ 1 Sparger
Lower side wall In-gold 1 Spare (Camera, CO2,…)
Hygienic socket 2 pH & dO2 probes
Temp. housing 1 PT100
Vessel bottom TC 3/4″ 1 Harvest valve
Jacket in-out TC 1/2″ 1 Steam In
TC 1/2″ 1 Water in
TC 1/2″ 1 Jacket out
1/2″ G 3 Electric Heaters in

Stirring

Drive Brushless Motor, Direct Assembly , 1-2000 rpm (bacterial), 1-500 (cell cultures)
Power 266 W
Impellers Select from: Rushtons impellers, Marine Impellers, Pitched blade

Thermoregulation

Control PID Control – Accuracy 0,1 °C – Jacket water heater

Gas Control & Gas Mixing

Sparger and overlay Gas Control TMFC
Gas Mixing (Air,CO2,O2,N2) n.1 TMFC + n.4 solenoid valves, n° of TMFC
Sparger type Select from: Toro type (ring), syntered microbubbling both provided with 0,2 µm filter
Exhaust Condenser and 0,2 µm filter

Controller

Master Controle Module from 1 to 4 units – Dimensions Height: 350 mm Largeness: 350 mm Depth: 350 mm
HMI with Leonardo software 9,7”
Temperature
Sensor PT100
Control system Measuring resident in Leonardo 2.0 software
Control range 0 – 150°C
pH
Sensor Digital Hamilton sensor
Control system Measuring resident in Leonardo 2.0 software
Control range 0 – 14
Operation temperature 0 – 130°C
Pressure range 0 – 6 bar
Actuator Cascade to peristlatic pumps for the addition of acid/base solutions or gas (CO2)
dO2
Sensor Digital Digital Optical Hamilton sensor
Control system Measuring resident in Leonardo 2.0 software
Control range 0,05 – 300% air saturation
Operation temperature -10 – 130°C
Pressure range 0 – 12 bar
Actuator Cascade to RPM, Gas Control, feedings,etc
dCO2
Sensor Mettler Toledo sensor
Control system Measuring resident in Leonardo 2.0 software
Control range 0,00-200% saturation
Operation temperature -20.0-150°C
Pressure range 0 – 4 bar
Turbidity
Sensor Mettler Toledo sensor
Control system Measuring resident in Leonardo 2.0 software
Measuring range 0-250 g/L, 10-4000 FTU
Cell density
Sensor Hamilton-Fogale sensor
Control system Measuring resident in Leonardo 2.0 software
Option 1 Total cell density (Two ranges: 10^5 to 10^8 mammalian cells/ml – 0.5 to 300 g/L dry weight)
Option 2 Viable cell density (Two ranges: 5×10^5 to 8×10^8 mammalian cells/ml – 5 to 200 g/L dry weight)
Redox (ORP)
Sensor Digital Hamilton sensor
Control system Measuring resident in Leonardo 2.0 software
Control range ±2000 mV
Operation temperature – 10 -130°C
Pressure range ≤ 6 bar
Conductivity
Sensor Digital Hamilton sensor
Control system Measuring resident in Leonardo 2.0 software
Control range 1 – 3000 μS/cm
Operation temperature 0 -130°C
Pressure range 0 – 20 bar
Weight
Sensor n.3 load cells
Control Measuring resident in Leonardo 2.0 software
Antifoam/Level
Sensor Solaris sensor
Control Measuring resident in Leonardo 2.0 software